2W9G

Wild-type Staphylococcus aureus DHFR in complex with NADPH and trimethoprim

Summary for 2W9G

Entry DOI	10.2210/pdb2w9g/pdb
Related	2W9H
Descriptor	DIHYDROFOLATE REDUCTASE, TRIMETHOPRIM, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywords	oxidoreductase, one-carbon metabolism
Biological source	STAPHYLOCOCCUS AUREUS
Total number of polymer chains	1
Total formula weight	19311.67
Authors	Soutter, H.H.,Miller, J.R. (deposition date: 2009-01-23, release date: 2009-03-24, Last modification date: 2011-07-13)
Primary citation	Heaslet, H.,Harris, M.,Fahnoe, K.,Sarver, R.,Putz, H.,Chang, J.,Subramanian, C.,Barreiro, G.,Miller, J.R. Structural Comparison of Chromosomal and Exogenous Dihydrofolate Reductase from Staphylococcus Aureus in Complex with the Potent Inhibitor Trimethoprim. Proteins, 76:706-, 2009 Cited by PubMed: 19280600 DOI: 10.1002/PROT.22383 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation