2W6N

Crystal structure of Biotin carboxylase from E. coli in complex with amino-oxazole fragment series

2W6N の概要

• エントリーDOI: 10.2210/pdb2w6n/pdb
• 関連するPDBエントリー: 1BNC 1DV1 1DV2 1K69 2GPS 2GPW 2J9G 2V58 2V59 2V5A 2VR1 2W6M 2W6O 2W6P 2W6Q 2W6Z 2W70 2W71 2W7C
• 分子名称: BIOTIN CARBOXYLASE, 2-AMINO-N,N-BIS(PHENYLMETHYL)-1,3-OXAZOLE-5-CARBOXAMIDE, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: ligase, atp-binding, fatty acid biosynthesis, nucleotide-binding, lipid synthesis, atp-grasp domain, fragment screening
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 99458.91

構造登録者

Mochalkin, I.,Miller, J.R. (登録日: 2008-12-18, 公開日: 2009-05-19, 最終更新日: 2023-12-13)

• 主引用文献: Mochalkin, I.,Miller, J.R.,Narasimhan, L.S.,Thanabal, V.,Erdman, P.,Cox, P.,Prasad, J.V.,Lightle, S.,Huband, M.,Stover, K.; Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches.; Acs Chem.Biol., 4:473-, 2009; PubMed: 19413326; DOI: 10.1021/CB9000102

実験手法

X-RAY DIFFRACTION (1.87 Å)