2W3W

MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR M. AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)

Summary for 2W3W

• Entry DOI: 10.2210/pdb2w3w/pdb
• Related: 2W3V
• Descriptor: DIHYDROFOLATE REDUCTASE, 6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: nonclassical antifolates, one-carbon metabolism, lipophilic antifolates, nadp, reductase, oxidoreductase
• Biological source: MYCOBACTERIUM AVIUM
• Total number of polymer chains: 1
• Total formula weight: 19565.68

Authors

Leung, A.K.W.,Reynolds, R.C.,Borhani, D.W. (deposition date: 2008-11-16, release date: 2009-11-17, Last modification date: 2023-12-13)

• Primary citation: Leung, A.K.W.,Ross, L.J.,Zywno-Van Ginkel, S.,Reynolds, R.C.,Seitz, L.E.,Pathak, V.,Barrow, W.W.,White, E.L.,Suling, W.J.,Piper, J.R.,Borhani, D.W.; Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate; To be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)