2W3W
MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR M. AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)
Summary for 2W3W
Entry DOI | 10.2210/pdb2w3w/pdb |
Related | 2W3V |
Descriptor | DIHYDROFOLATE REDUCTASE, 6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | nonclassical antifolates, one-carbon metabolism, lipophilic antifolates, nadp, reductase, oxidoreductase |
Biological source | MYCOBACTERIUM AVIUM |
Total number of polymer chains | 1 |
Total formula weight | 19565.68 |
Authors | Leung, A.K.W.,Reynolds, R.C.,Borhani, D.W. (deposition date: 2008-11-16, release date: 2009-11-17, Last modification date: 2023-12-13) |
Primary citation | Leung, A.K.W.,Ross, L.J.,Zywno-Van Ginkel, S.,Reynolds, R.C.,Seitz, L.E.,Pathak, V.,Barrow, W.W.,White, E.L.,Suling, W.J.,Piper, J.R.,Borhani, D.W. Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate To be Published, |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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