Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE VG9 A 1168 |
Chain | Residue |
A | VAL9 |
A | NDP1169 |
A | HOH2087 |
A | TRP10 |
A | ALA11 |
A | ILE24 |
A | ASP31 |
A | LEU32 |
A | PHE35 |
A | ILE102 |
A | TYR108 |
site_id | AC2 |
Number of Residues | 31 |
Details | BINDING SITE FOR RESIDUE NDP A 1169 |
Chain | Residue |
A | TRP10 |
A | ALA11 |
A | ILE18 |
A | GLY19 |
A | GLY22 |
A | ASP23 |
A | ILE24 |
A | GLY47 |
A | ARG48 |
A | ARG49 |
A | THR50 |
A | VAL69 |
A | SER70 |
A | ARG71 |
A | ARG72 |
A | GLY84 |
A | ILE102 |
A | GLY104 |
A | ALA105 |
A | GLN106 |
A | ILE107 |
A | TYR108 |
A | LEU110 |
A | VG91168 |
A | HOH2048 |
A | HOH2121 |
A | HOH2122 |
A | HOH2123 |
A | HOH2124 |
A | HOH2125 |
A | HOH2126 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrggdIPWsvpe.DltrFkevT |
Chain | Residue | Details |
A | VAL17-THR39 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
A | ILE24 | |
A | ASP31 | |