Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0044281 | biological_process | small molecule metabolic process |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE VG9 A 1168 |
| Chain | Residue |
| A | VAL9 |
| A | NDP1169 |
| A | HOH2087 |
| A | TRP10 |
| A | ALA11 |
| A | ILE24 |
| A | ASP31 |
| A | LEU32 |
| A | PHE35 |
| A | ILE102 |
| A | TYR108 |
| site_id | AC2 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NDP A 1169 |
| Chain | Residue |
| A | TRP10 |
| A | ALA11 |
| A | ILE18 |
| A | GLY19 |
| A | GLY22 |
| A | ASP23 |
| A | ILE24 |
| A | GLY47 |
| A | ARG48 |
| A | ARG49 |
| A | THR50 |
| A | VAL69 |
| A | SER70 |
| A | ARG71 |
| A | ARG72 |
| A | GLY84 |
| A | ILE102 |
| A | GLY104 |
| A | ALA105 |
| A | GLN106 |
| A | ILE107 |
| A | TYR108 |
| A | LEU110 |
| A | VG91168 |
| A | HOH2048 |
| A | HOH2121 |
| A | HOH2122 |
| A | HOH2123 |
| A | HOH2124 |
| A | HOH2125 |
| A | HOH2126 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrggdIPWsvpe.DltrFkevT |
| Chain | Residue | Details |
| A | VAL17-THR39 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dhf |
| Chain | Residue | Details |
| A | ILE24 | |
| A | ASP31 | |
