2VWC

STRUCTURE OF THE HSP90 INHIBITOR MACBECIN BOUND TO THE N-TERMINUS OF YEAST HSP90.

「2VLS」から置き換えられました

2VWC の概要

• エントリーDOI: 10.2210/pdb2vwc/pdb
• 関連するPDBエントリー: 1A4H 1AH6 1AH8 1AM1 1AMW 1BGQ 1HK7 1US7 1USU 1USV 1ZW9 1ZWH 2AKP 2BRC 2BRE 2CG9 2CGE 2CGF 2IWS 2IWU 2IWX 2VW5
• 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, MACBECIN, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: chaperone, chaperone-complex, inhibitor, heat shock, atp-binding, stress response, multigene family, nucleotide-binding
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• 細胞内の位置: Cytoplasm: P02829
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25427.04

構造登録者

Roe, S.M.,Prodromou, C.,Pearl, L.H. (登録日: 2008-06-20, 公開日: 2008-07-01, 最終更新日: 2023-12-13)

主引用文献

Martin, C.J.,Gaisser, S.,Challis, I.R.,Carletti, I.,Wilkinson, B.,Gregory, M.,Prodromou, C.,Roe, S.M.,Pearl, L.H.,Boyd, S.M.,Zhang, M.Q.
Molecular Characterisation of Macbecin as an Hsp90 Inhibitor
J.Med.Chem., 51:2853-, 2008

PubMed Abstract: Macbecin compares favorably to geldanamycin as an Hsp90 inhibitor, being more soluble, stable, more potently inhibiting ATPase activity (IC50 = 2 microM) and binding with higher affinity (Kd = 0.24 microM). Structural studies reveal significant differences in their Hsp90 binding characteristics, and macbecin-induced tumor cell growth inhibition is accompanied by characteristic degradation of Hsp90 client proteins. Macbecin significantly reduced tumor growth rates (minimum T/C: 32%) in a DU145 murine xenograft. Macbecin thus represents an attractive lead for further optimization.

PubMed: 18357975
DOI: 10.1021/JM701558C

実験手法

X-RAY DIFFRACTION (2.4 Å)