2VRW
Critical structural role for the PH and C1 domains of the Vav1 exchange factor
Summary for 2VRW
Entry DOI | 10.2210/pdb2vrw/pdb |
Related | 1E96 1F5X 1FOE 1G4U 1GCP 1GCQ 1HE1 1HH4 1I4D 1I4L 1I4T 1K1Z 1MH1 1RYF 1RYH 2FJU |
Descriptor | RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, PROTO-ONCOGENE VAV, ZINC ION, ... (4 entities in total) |
Functional Keywords | lipoprotein, gtp-binding, metal-binding, proto-oncogene, phosphoprotein, exchange factor, rac, vav, gtpase, membrane, sh2 domain, sh3 domain, methylation, zinc-finger, prenylation, guanine-nucleotide releasing factor, phorbol-ester binding, adp-ribosylation, nucleotide-binding, signaling protein |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P63000 |
Total number of polymer chains | 2 |
Total formula weight | 68092.80 |
Authors | Rapley, J.,Tybulewicz, V.,Rittinger, K. (deposition date: 2008-04-16, release date: 2008-06-17, Last modification date: 2024-05-08) |
Primary citation | Rapley, J.,Tybulewicz, V.,Rittinger, K. Crucial Structural Role for the Ph and C1 Domains of the Vav1 Exchange Factor. Embo Rep., 9:655-, 2008 Cited by PubMed: 18511940DOI: 10.1038/EMBOR.2008.80 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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