2VRW

Critical structural role for the PH and C1 domains of the Vav1 exchange factor

2VRW の概要

• エントリーDOI: 10.2210/pdb2vrw/pdb
• 関連するPDBエントリー: 1E96 1F5X 1FOE 1G4U 1GCP 1GCQ 1HE1 1HH4 1I4D 1I4L 1I4T 1K1Z 1MH1 1RYF 1RYH 2FJU
• 分子名称: RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, PROTO-ONCOGENE VAV, ZINC ION, ... (4 entities in total)
• 機能のキーワード: lipoprotein, gtp-binding, metal-binding, proto-oncogene, phosphoprotein, exchange factor, rac, vav, gtpase, membrane, sh2 domain, sh3 domain, methylation, zinc-finger, prenylation, guanine-nucleotide releasing factor, phorbol-ester binding, adp-ribosylation, nucleotide-binding, signaling protein
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P63000
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68092.80

構造登録者

Rapley, J.,Tybulewicz, V.,Rittinger, K. (登録日: 2008-04-16, 公開日: 2008-06-17, 最終更新日: 2011-07-13)

• 主引用文献: Rapley, J.,Tybulewicz, V.,Rittinger, K.; Crucial Structural Role for the Ph and C1 Domains of the Vav1 Exchange Factor.; Embo Rep., 9:655-, 2008; PubMed: 18511940; DOI: 10.1038/EMBOR.2008.80

実験手法

X-RAY DIFFRACTION (1.85 Å)