2VHS

Cathsilicatein, a chimera

Summary for 2VHS

Entry DOI	10.2210/pdb2vhs/pdb
Descriptor	CATHSILICATEIN, SULFATE ION (3 entities in total)
Functional Keywords	zymogen, protease, lysosome, hydrolase, glycoprotein, thiol protease, silica condensation
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Lysosome: P07711
Total number of polymer chains	4
Total formula weight	95645.98
Authors	Fairhead, M.,Kowatz, T.,McMahon, S.A.,Carter, L.G.,Oke, M.,Johnson, K.A.,Liu, H.,Naismith, J.H.,Wal, C.F.V.D. (deposition date: 2007-11-24, release date: 2008-03-11, Last modification date: 2023-12-13)
Primary citation	Fairhead, M.,Johnson, K.A.,Kowatz, T.,Mcmahon, S.A.,Carter, L.G.,Oke, M.,Liu, H.,Naismith, J.H.,Van Der Walle, C.F. Crystal Structure and Silica Condensing Activities of Silicatein Alpha-Cathepsin L Chimeras. Chem. Commun., :1765-, 2008 Cited by PubMed Abstract: Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5 A crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation. PubMed: 18379686 DOI: 10.1039/B718264C PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation