2VHS
Cathsilicatein, a chimera
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A1221 |
| Chain | Residue |
| A | GLN19 |
| A | HOH2303 |
| A | GLY23 |
| A | ALA24 |
| A | SER25 |
| A | ASN162 |
| A | HIS163 |
| A | HOH2300 |
| A | HOH2301 |
| A | HOH2302 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B1221 |
| Chain | Residue |
| B | GLN19 |
| B | GLY23 |
| B | ALA24 |
| B | SER25 |
| B | ASN162 |
| B | HIS163 |
| B | HOH2058 |
| B | HOH2060 |
| B | HOH2262 |
| B | HOH2263 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 C1221 |
| Chain | Residue |
| C | GLN19 |
| C | GLY23 |
| C | ALA24 |
| C | SER25 |
| C | ASN162 |
| C | HIS163 |
| C | HOH2254 |
| C | HOH2302 |
| C | HOH2303 |
| C | HOH2304 |
| C | HOH2305 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 D1221 |
| Chain | Residue |
| D | GLN19 |
| D | GLY23 |
| D | ALA24 |
| D | SER25 |
| D | ASN162 |
| D | HIS163 |
| D | HOH2294 |
| D | HOH2295 |
| D | HOH2296 |
| D | HOH2297 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D1222 |
| Chain | Residue |
| A | LYS124 |
| D | HIS140 |
| D | GLU141 |
| D | HOH2298 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C1222 |
| Chain | Residue |
| B | LYS124 |
| C | HIS140 |
| C | GLU141 |
| C | HOH2306 |
| C | HOH2307 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A1222 |
| Chain | Residue |
| A | HIS140 |
| A | GLU141 |
| D | LYS124 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B1222 |
| Chain | Residue |
| B | HIS140 |
| B | GLU141 |
| B | HOH2264 |
| C | LYS124 |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAMLVVGYG |
| Chain | Residue | Details |
| A | LEU161-GLY171 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM |
| Chain | Residue | Details |
| A | TYR182-MET201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"9468501","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Active site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HFV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 9pap |
| Chain | Residue | Details |
| A | ASN187 | |
| A | GLN19 | |
| A | HIS163 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 9pap |
| Chain | Residue | Details |
| B | ASN187 | |
| B | GLN19 | |
| B | HIS163 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 9pap |
| Chain | Residue | Details |
| C | ASN187 | |
| C | GLN19 | |
| C | HIS163 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 9pap |
| Chain | Residue | Details |
| D | ASN187 | |
| D | GLN19 | |
| D | HIS163 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 9pap |
| Chain | Residue | Details |
| A | ASN187 | |
| A | GLN19 | |
| A | SER25 | |
| A | HIS163 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 9pap |
| Chain | Residue | Details |
| B | ASN187 | |
| B | GLN19 | |
| B | SER25 | |
| B | HIS163 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 9pap |
| Chain | Residue | Details |
| C | ASN187 | |
| C | GLN19 | |
| C | SER25 | |
| C | HIS163 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 9pap |
| Chain | Residue | Details |
| D | ASN187 | |
| D | GLN19 | |
| D | SER25 | |
| D | HIS163 |
