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2VGQ

Crystal Structure of Human IPS-1 CARD

Summary for 2VGQ
Entry DOI10.2210/pdb2vgq/pdb
Related1A7L 1ANF 1DMB 1EZ9 1EZO 1EZP 1FQA 1FQB 1FQC 1FQD 1HSJ 1IUD 1JVX 1JVY 1JW4 1JW5 1LAX 1LLS 1MDP 1MDQ 1MG1 1MH3 1MH4 1MPB 1MPC 1MPD 1N3W 1N3X 1NL5 1NMU 1OMP 1PEB 1R6Z 1SVX 1T0K 1Y4C 1YTV 1ZIU 1ZJL 1ZKB 1ZMG 2D21 2H25 3MBP
Related PRD IDPRD_900010
DescriptorSugar ABC transporter substrate-binding protein,Mitochondrial antiviral-signaling protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, SULFATE ION, ... (4 entities in total)
Functional Keywordsimmune system/transport, ips1/mavs/visa/cardif, caspase activation, caspase recruitment domain, innate immunity, fusion protein, sugar transport, transport, immune system, chimera, immune system-transport complex
Biological sourceEscherichia coli
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Total number of polymer chains1
Total formula weight54558.22
Authors
Potter, J.A.,Randall, R.E.,Taylor, G.L. (deposition date: 2007-11-15, release date: 2007-12-11, Last modification date: 2024-05-08)
Primary citationPotter, J.A.,Randall, R.E.,Taylor, G.L.
Crystal Structure of Human Ips-1 Caspase Activation Recruitment Domain
Bmc Struct.Biol., 8:11-, 2008
Cited by
PubMed Abstract: IPS-1/MAVS/VISA/Cardif is an adaptor protein that plays a crucial role in the induction of interferons in response to viral infection. In the initial stage of the intracellular antiviral response two RNA helicases, retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-association gene 5 (MDA5), are independently able to bind viral RNA in the cytoplasm. The 62 kDa protein IPS-1/MAVS/VISA/Cardif contains an N-terminal caspase activation and recruitment (CARD) domain that associates with the CARD regions of RIG-I and MDA5, ultimately leading to the induction of type I interferons. As a first step towards understanding the molecular basis of this important adaptor protein we have undertaken structural studies of the IPS-1 MAVS/VISA/Cardif CARD region.
PubMed: 18307765
DOI: 10.1186/1472-6807-8-11
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

235183

數據於2025-04-23公開中

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