2VGQ

Crystal Structure of Human IPS-1 CARD

Summary for 2VGQ

• Entry DOI: 10.2210/pdb2vgq/pdb
• Related: 1A7L 1ANF 1DMB 1EZ9 1EZO 1EZP 1FQA 1FQB 1FQC 1FQD 1HSJ 1IUD 1JVX 1JVY 1JW4 1JW5 1LAX 1LLS 1MDP 1MDQ 1MG1 1MH3 1MH4 1MPB 1MPC 1MPD 1N3W 1N3X 1NL5 1NMU 1OMP 1PEB 1R6Z 1SVX 1T0K 1Y4C 1YTV 1ZIU 1ZJL 1ZKB 1ZMG 2D21 2H25 3MBP
• Related PRD ID: PRD_900010
• Descriptor: Sugar ABC transporter substrate-binding protein,Mitochondrial antiviral-signaling protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, SULFATE ION, ... (4 entities in total)
• Functional Keywords: immune system/transport, ips1/mavs/visa/cardif, caspase activation, caspase recruitment domain, innate immunity, fusion protein, sugar transport, transport, immune system, chimera, immune system-transport complex
• Biological source: Escherichia coli; More
• Total number of polymer chains: 1
• Total formula weight: 54558.22

Authors

Potter, J.A.,Randall, R.E.,Taylor, G.L. (deposition date: 2007-11-15, release date: 2007-12-11, Last modification date: 2024-05-08)

Primary citation

Potter, J.A.,Randall, R.E.,Taylor, G.L.
Crystal Structure of Human Ips-1 Caspase Activation Recruitment Domain
Bmc Struct.Biol., 8:11-, 2008

PubMed Abstract: IPS-1/MAVS/VISA/Cardif is an adaptor protein that plays a crucial role in the induction of interferons in response to viral infection. In the initial stage of the intracellular antiviral response two RNA helicases, retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-association gene 5 (MDA5), are independently able to bind viral RNA in the cytoplasm. The 62 kDa protein IPS-1/MAVS/VISA/Cardif contains an N-terminal caspase activation and recruitment (CARD) domain that associates with the CARD regions of RIG-I and MDA5, ultimately leading to the induction of type I interferons. As a first step towards understanding the molecular basis of this important adaptor protein we have undertaken structural studies of the IPS-1 MAVS/VISA/Cardif CARD region.

PubMed: 18307765
DOI: 10.1186/1472-6807-8-11

Experimental method

X-RAY DIFFRACTION (2.1 Å)