2VGQ

Crystal Structure of Human IPS-1 CARD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Sugar ABC transporter substrate-binding protein,Mitochondrial antiviral-signaling protein	polymer	477	53411.3	1	UniProt (A0A0B1N7A9) UniProt (Q7Z434) Pfam (PF01547) Pfam (PF16739) UniProt (by SIFTS) (P0AEX9) In PDB	Escherichia coli	MAVS,CARD adapter inducing interferon beta,Cardif,Interferon beta promoter stimulator protein 1,IPS-1,Putative NF-kappa-B-activating protein 031N,Virus-induced-signaling adapter,VISA
2	B	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		666.6	1	In PDB BIRD (PRD_900010) GlyTouCan (G87171PZ)		alpha-maltotetraose
3	A	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
4		water	water		18.0	203	Chemie (HOH)

Sequence modifications

A: 1 - 362 (UniProt: A0A0B1N7A9)

PDB	External Database	Details
Met -14	-	initiating methionine
Lys -13	-	expression tag
Tyr -12	-	expression tag
Tyr -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
Asp -4	-	expression tag
Tyr -3	-	expression tag
Asp -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag
Asp 363	-	linker
Ala 364	-	linker
Gln 365	-	linker
Thr 366	-	linker
Asn 367	-	linker
Ser 368	-	linker
Ala 369	-	linker

A: 370 - 462 (UniProt: Q7Z434)

PDB	External Database	Details
Met 370	Met 1	linker
Ala 371	Pro 2	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	53411.3
Branched	Number of molecules	1
	Total formula weight	666.6
Non-Polymers*	Number of molecules	5
	Total formula weight	480.3
All*	Total formula weight	54558.2

*Water molecules are not included.