2VGO

Crystal structure of Aurora B kinase in complex with Reversine inhibitor

Summary for 2VGO

• Entry DOI: 10.2210/pdb2vgo/pdb
• Related: 2BFX 2BFY 2VGP
• Descriptor: SERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine, ... (4 entities in total)
• Functional Keywords: nucleotide-binding, serine/threonine-protein kinase, atp-binding, transferase, coiled coil, cell division, kinase, cancer, incenp, nucleus, mitosis, aurora b, metal-binding, aminothiazole, phosphorylation, magnesium, cell cycle, centromere, microtubule
• Biological source: XENOPUS LAEVIS (AFRICAN CLAWED FROG); More
• Cellular location: Nucleus: Q6DE08; Chromosome, centromere: O13024
• Total number of polymer chains: 4
• Total formula weight: 78010.22

Authors

D'Alise, A.M.,Amabile, G.,Iovino, M.,Di Giorgio, F.P.,Bartiromo, M.,Sessa, F.,Villa, F.,Musacchio, A.,Cortese, R. (deposition date: 2007-11-15, release date: 2008-10-28, Last modification date: 2024-01-31)

• Primary citation: D'Alise, A.M.,Amabile, G.,Iovino, M.,Di Giorgio, F.P.,Bartiromo, M.,Sessa, F.,Villa, F.,Musacchio, A.,Cortese, R.; Reversine, a Novel Aurora Kinases Inhibitor, Inhibits Colony Formation of Human Acute Myeloid Leukemia Cells.; Mol.Cancer Ther., 7:1140-, 2008; PubMed: 18483302; DOI: 10.1158/1535-7163.MCT-07-2051

Experimental method

X-RAY DIFFRACTION (1.7 Å)