2VD1
Complex structure of prostaglandin D2 synthase at 2.25A.
Summary for 2VD1
Entry DOI | 10.2210/pdb2vd1/pdb |
Related | 1IYH 1IYI 1V40 2VCQ 2VCW 2VCX 2VCZ 2VD0 |
Descriptor | GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid, ... (5 entities in total) |
Functional Keywords | prostaglandin biosynthesis, fatty acid biosynthesis, prostaglandin d2 synthase, pgds, asthma, cytoplasm, isomerase, lipid synthesis |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: O60760 |
Total number of polymer chains | 4 |
Total formula weight | 95081.28 |
Authors | Hohwy, M.,Spadola, L.,Lundquist, B.,von Wachenfeldt, K.,Persdotter, S.,Hawtin, P.,Dahmen, J.,Groth-Clausen, I.,Folmer, R.H.A.,Edman, K. (deposition date: 2007-09-28, release date: 2008-04-15, Last modification date: 2023-12-13) |
Primary citation | Hohwy, M.,Spadola, L.,Lundquist, B.,Hawtin, P.,Dahmen, J.,Groth-Clausen, I.,Nilsson, E.,Persdotter, S.,Von Wachenfeldt, K.,Folmer, R.H.A.,Edman, K. Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design. J.Med.Chem., 51:2178-, 2008 Cited by PubMed: 18341273DOI: 10.1021/JM701509K PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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