2VD1
Complex structure of prostaglandin D2 synthase at 2.25A.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004667 | molecular_function | prostaglandin-D synthase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006693 | biological_process | prostaglandin metabolic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0007626 | biological_process | locomotory behavior |
| A | 0019371 | biological_process | cyclooxygenase pathway |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0004667 | molecular_function | prostaglandin-D synthase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006693 | biological_process | prostaglandin metabolic process |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0007165 | biological_process | signal transduction |
| B | 0007626 | biological_process | locomotory behavior |
| B | 0019371 | biological_process | cyclooxygenase pathway |
| B | 0042803 | molecular_function | protein homodimerization activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004364 | molecular_function | glutathione transferase activity |
| C | 0004667 | molecular_function | prostaglandin-D synthase activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006693 | biological_process | prostaglandin metabolic process |
| C | 0006749 | biological_process | glutathione metabolic process |
| C | 0007165 | biological_process | signal transduction |
| C | 0007626 | biological_process | locomotory behavior |
| C | 0019371 | biological_process | cyclooxygenase pathway |
| C | 0042803 | molecular_function | protein homodimerization activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004364 | molecular_function | glutathione transferase activity |
| D | 0004667 | molecular_function | prostaglandin-D synthase activity |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006693 | biological_process | prostaglandin metabolic process |
| D | 0006749 | biological_process | glutathione metabolic process |
| D | 0007165 | biological_process | signal transduction |
| D | 0007626 | biological_process | locomotory behavior |
| D | 0019371 | biological_process | cyclooxygenase pathway |
| D | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE D28 B1200 |
| Chain | Residue |
| B | PHE9 |
| B | GSH1202 |
| B | HOH2104 |
| B | MET11 |
| B | GLY13 |
| B | ARG14 |
| B | GLN36 |
| B | ASP96 |
| B | MET99 |
| B | TRP104 |
| B | TYR152 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B1201 |
| Chain | Residue |
| A | HOH2043 |
| A | HOH2046 |
| A | HOH2048 |
| B | HOH2056 |
| B | HOH2059 |
| B | HOH2061 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GSH A1200 |
| Chain | Residue |
| A | TYR8 |
| A | ARG14 |
| A | TRP39 |
| A | LYS43 |
| A | GLY49 |
| A | LYS50 |
| A | ILE51 |
| A | GLN63 |
| A | SER64 |
| A | HOH2023 |
| A | HOH2047 |
| B | ASP97 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GSH B1202 |
| Chain | Residue |
| A | ASP97 |
| B | TYR8 |
| B | ARG14 |
| B | TRP39 |
| B | LYS43 |
| B | LYS50 |
| B | ILE51 |
| B | GLN63 |
| B | SER64 |
| B | D281200 |
| B | HOH2010 |
| B | HOH2060 |
| B | HOH2107 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GSH C1200 |
| Chain | Residue |
| C | TYR8 |
| C | ARG14 |
| C | TRP39 |
| C | LYS43 |
| C | LYS50 |
| C | ILE51 |
| C | GLN63 |
| C | SER64 |
| C | HOH2085 |
| C | HOH2086 |
| C | HOH2087 |
| D | ASP97 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GSH D1200 |
| Chain | Residue |
| C | ASP97 |
| D | TYR8 |
| D | ARG14 |
| D | TRP39 |
| D | LYS43 |
| D | GLY49 |
| D | LYS50 |
| D | ILE51 |
| D | PRO52 |
| D | GLN63 |
| D | SER64 |
| D | HOH2020 |
| D | HOH2038 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 308 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 354 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12627223","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15113825","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16547010","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18341273","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19939518","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| A | TYR8 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| B | TYR8 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| C | TYR8 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| D | TYR8 |
