2UXX

Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct

2UXX の概要

• エントリーDOI: 10.2210/pdb2uxx/pdb
• 関連するPDBエントリー: 2COM 2H94 2IW5 2UXN
• 分子名称: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FAD-trans-2-Phenylcyclopropylamine Adduct, ... (6 entities in total)
• 機能のキーワード: oxidoreductase-repressor complex, histone demethylase, oxidoreductase, nuclear protein, phosphorylation, transcription regulation, tranylcypromine, chromatin regulator, nucleosomes, transcription, host-virus interaction, chromatin demethylation, fad, lsd1, corest, repressor, depression, oxidoreductase/repressor
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 101691.88

構造登録者

Yang, M.,Culhane, J.C.,Machius, M.,Cole, P.A.,Yu, H. (登録日: 2007-03-30, 公開日: 2007-08-21, 最終更新日: 2024-05-08)

• 主引用文献: Yang, M.,Culhane, J.C.,Szewczuk, L.M.,Jalili, P.,Ball, H.L.,Machius, M.,Cole, P.A.,Yu, H.; Structural Basis for the Inhibition of the Lsd1 Histone Demethylase by the Antidepressant Trans-2-Phenylcyclopropylamine.; Biochemistry, 46:8058-, 2007; PubMed: 17569509; DOI: 10.1021/BI700664Y

実験手法

X-RAY DIFFRACTION (2.74 Å)