2RQZ

Structure of sugar modified epidermal growth factor-like repeat 12 of mouse Notch-1 receptor

Summary for 2RQZ

• Entry DOI: 10.2210/pdb2rqz/pdb
• Related: 1TOZ 2JOA 2RR0 2RR2
• NMR Information: BMRB: 11006
• Descriptor: Neurogenic locus notch homolog protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose (2 entities in total)
• Functional Keywords: notch, glycopeptide, o-linked fucose, activator, fringe, ank repeat, developmental protein, differentiation, egf-like domain, glycoprotein, metal-binding, notch signaling pathway, nucleus, phosphorylation, receptor, transcription, transcription regulation, transmembrane, cell membrane, disulfide bond, phosphoprotein
• Biological source: Mus musculus (MOUSE)
• Total number of polymer chains: 1
• Total formula weight: 4586.05

Authors

Shimizu, K.,Fujitani, N.,Hosoguchi, K.,Nishimura, S. (deposition date: 2010-02-26, release date: 2010-10-13, Last modification date: 2020-07-29)

• Primary citation: Hiruma-Shimizu, K.,Hosoguchi, K.,Liu, Y.,Fujitani, N.,Ohta, T.,Hinou, H.,Matsushita, T.,Shimizu, H.,Feizi, T.,Nishimura, S.; Chemical Synthesis, Folding, and Structural Insights into O-Fucosylated Epidermal Growth Factor-like Repeat 12 of Mouse Notch-1 Receptor; J.Am.Chem.Soc., 132:14857-14865, 2010; PubMed: 20883017; DOI: 10.1021/ja105216u

Experimental method

SOLUTION NMR