2RJP
Crystal structure of ADAMTS4 with inhibitor bound
Summary for 2RJP
Entry DOI | 10.2210/pdb2rjp/pdb |
Related | 2RJQ 3B2Z |
Descriptor | ADAMTS-4, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | metalloprotease domain, aggrecanase, cleavage on pair of basic residues, extracellular matrix, glycoprotein, hydrolase, metal-binding, polymorphism, secreted, zinc, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix (By similarity): O75173 |
Total number of polymer chains | 4 |
Total formula weight | 139667.67 |
Authors | Mosyak, L.,Stahl, M.,Somers, W. (deposition date: 2007-10-15, release date: 2007-12-11, Last modification date: 2021-10-20) |
Primary citation | Mosyak, L.,Georgiadis, K.,Shane, T.,Svenson, K.,Hebert, T.,McDonagh, T.,Mackie, S.,Olland, S.,Lin, L.,Zhong, X.,Kriz, R.,Reifenberg, E.L.,Collins-Racie, L.A.,Corcoran, C.,Freeman, B.,Zollner, R.,Marvell, T.,Vera, M.,Sum, P.E.,Lavallie, E.R.,Stahl, M.,Somers, W. Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci., 17:16-21, 2008 Cited by PubMed: 18042673DOI: 10.1110/ps.073287008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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