2RI7

Crystal structure of PHD finger-linker-bromodomain Y17E mutant from human BPTF in the H3(1-9)K4ME2 bound state

2RI7 の概要

• エントリーDOI: 10.2210/pdb2ri7/pdb
• 関連するPDBエントリー: 2F6J 2F6N 2FSA
• 分子名称: Nucleosome-remodeling factor subunit BPTF, histone H3.1, ZINC ION, ... (6 entities in total)
• 機能のキーワード: zinc finger, alpha-helical bundle, dimethyl-lysine, bromodomain, chromatin regulator, metal-binding, nucleus, phosphorylation, transcription, transcription regulation, zinc-finger, transcription-nuclear protein complex, transcription/nuclear protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: Q12830; Nucleus: P68431
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 21636.30

構造登録者

Li, H.,Patel, D.J. (登録日: 2007-10-10, 公開日: 2007-12-11, 最終更新日: 2023-08-30)

• 主引用文献: Li, H.,Fischle, W.,Wang, W.,Duncan, E.M.,Liang, L.,Murakami-Ishibe, S.,Allis, C.D.,Patel, D.J.; Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger.; Mol.Cell, 28:677-691, 2007; PubMed: 18042461; DOI: 10.1016/j.molcel.2007.10.023

実験手法

X-RAY DIFFRACTION (1.45 Å)