2R8O

Transketolase from E. coli in complex with substrate D-xylulose-5-phosphate

2R8O の概要

• エントリーDOI: 10.2210/pdb2r8o/pdb
• 関連するPDBエントリー: 1QGD 2R5N 2R8P
• 分子名称: Transketolase 1, CALCIUM ION, 2-C-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thia zol-3-ium-2-yl}-5-O-phosphono-D-xylitol, ... (5 entities in total)
• 機能のキーワード: reaction intermediate, calcium, metal-binding, thiamine pyrophosphate, transferase
• 由来する生物種: Escherichia coli K12
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 148316.77

構造登録者

Wille, G.,Asztalos, P.,Weiss, M.S.,Tittmann, K. (登録日: 2007-09-11, 公開日: 2007-12-11, 最終更新日: 2024-02-21)

• 主引用文献: Asztalos, P.,Parthier, C.,Golbik, R.,Kleinschmidt, M.,Hubner, G.,Weiss, M.S.,Friedemann, R.,Wille, G.,Tittmann, K.; Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate.; Biochemistry, 46:12037-12052, 2007; PubMed: 17914867; DOI: 10.1021/bi700844m

実験手法

X-RAY DIFFRACTION (1.47 Å)