2R2M

2-(2-Chloro-6-Fluorophenyl)Acetamides as Potent Thrombin Inhibitors

Summary for 2R2M

Entry DOI	10.2210/pdb2r2m/pdb
Descriptor	Thrombin light chain, Thrombin heavy chain, Hirudin-3A, ... (5 entities in total)
Functional Keywords	thrombin, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, kringle, protease, secreted, serine protease, zymogen, protease inhibitor, serine protease inhibitor, sulfation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734 Secreted: P28507
Total number of polymer chains	3
Total formula weight	34711.00
Authors	Spurlino, J. (deposition date: 2007-08-27, release date: 2008-08-26, Last modification date: 2011-07-13)
Primary citation	Lee, L.,Kreutter, K.D.,Pan, W.,Crysler, C.,Spurlino, J.,Player, M.R.,Tomczuk, B.,Lu, T. 2-(2-Chloro-6-Fluorophenyl)Acetamides as Potent Thrombin Inhibitors Bioorg.Med.Chem.Lett., 17:6266-6269, 2007 Cited by PubMed: 17889527 DOI: 10.1016/j.bmcl.2007.09.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation