2QQL
Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab
Summary for 2QQL
Entry DOI | 10.2210/pdb2qql/pdb |
Related | 2QQI 2QQJ 2QQK 2QQM 2QQN 2QQO |
Descriptor | Neuropilin-2, Antibody Heavy Chain, Antibody Light Chain (3 entities in total) |
Functional Keywords | vegf receptor, semaphorin receptor, phage-derived antibody, developmental protein, differentiation, glycoprotein, membrane, neurogenesis, transmembrane, hormone, signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane ; Single-pass type I membrane protein . Isoform s9: Secreted : O60462 |
Total number of polymer chains | 3 |
Total formula weight | 113576.04 |
Authors | Appleton, B.A.,Wiesmann, C. (deposition date: 2007-07-26, release date: 2007-11-20, Last modification date: 2023-08-30) |
Primary citation | Appleton, B.A.,Wu, P.,Maloney, J.,Yin, J.,Liang, W.C.,Stawicki, S.,Mortara, K.,Bowman, K.K.,Elliott, J.M.,Desmarais, W.,Bazan, J.F.,Bagri, A.,Tessier-Lavigne, M.,Koch, A.W.,Wu, Y.,Watts, R.J.,Wiesmann, C. Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding Embo J., 26:4902-4912, 2007 Cited by PubMed: 17989695DOI: 10.1038/sj.emboj.7601906 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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