2QOS

Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8

Summary for 2QOS

• Entry DOI: 10.2210/pdb2qos/pdb
• Related: 1IW2 1LF7 2OVA 2OVD 2OVE
• Descriptor: Complement component 8, gamma polypeptide, Complement component C8 alpha chain (3 entities in total)
• Functional Keywords: beta barrel, lipocalin, cleavage on pair of basic residues, complement alternate pathway, complement pathway, cytolysis, egf-like domain, glycoprotein, immune response, innate immunity, membrane attack complex, polymorphism, secreted, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P07357
• Total number of polymer chains: 2
• Total formula weight: 20560.16

Authors

Lovelace, L.L.,Chiswell, B.,Slade, D.J.,Sodetz, J.M.,Lebioda, L. (deposition date: 2007-07-20, release date: 2007-10-16, Last modification date: 2023-08-30)

• Primary citation: Lovelace, L.L.,Chiswell, B.,Slade, D.J.,Sodetz, J.M.,Lebioda, L.; Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: Implications for C8gamma ligand binding.; Mol.Immunol., 45:750-756, 2008; PubMed: 17692377; DOI: 10.1016/j.molimm.2007.06.359

Experimental method

X-RAY DIFFRACTION (1.81 Å)