2QOS

Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8

2QOS の概要

• エントリーDOI: 10.2210/pdb2qos/pdb
• 関連するPDBエントリー: 1IW2 1LF7 2OVA 2OVD 2OVE
• 分子名称: Complement component 8, gamma polypeptide, Complement component C8 alpha chain (3 entities in total)
• 機能のキーワード: beta barrel, lipocalin, cleavage on pair of basic residues, complement alternate pathway, complement pathway, cytolysis, egf-like domain, glycoprotein, immune response, innate immunity, membrane attack complex, polymorphism, secreted, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P07357
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20560.16

構造登録者

Lovelace, L.L.,Chiswell, B.,Slade, D.J.,Sodetz, J.M.,Lebioda, L. (登録日: 2007-07-20, 公開日: 2007-10-16, 最終更新日: 2023-08-30)

• 主引用文献: Lovelace, L.L.,Chiswell, B.,Slade, D.J.,Sodetz, J.M.,Lebioda, L.; Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: Implications for C8gamma ligand binding.; Mol.Immunol., 45:750-756, 2008; PubMed: 17692377; DOI: 10.1016/j.molimm.2007.06.359

実験手法

X-RAY DIFFRACTION (1.81 Å)