2QMG
Structure of BACE Bound to SCH745966
Summary for 2QMG
Entry DOI | 10.2210/pdb2qmg/pdb |
Related | 2qk5 2qkj 2qmd 2qmf 2qp8 |
Descriptor | Beta-secretase 1, N-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-[(2R,4R)-4-PHENOXYPYRROLIDIN-2-YL]ETHYL}-3-{[(2R)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]CARBONYL}-5-METHYLBENZAMIDE, D(-)-TARTARIC ACID, ... (4 entities in total) |
Functional Keywords | bace1, protease, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, transmembrane, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 2 |
Total formula weight | 89394.67 |
Authors | Strickland, C.O.,Iserloh, U. (deposition date: 2007-07-16, release date: 2008-03-18, Last modification date: 2017-10-25) |
Primary citation | Iserloh, U.,Pan, J.,Stamford, A.W.,Kennedy, M.E.,Zhang, Q.,Zhang, L.,Parker, E.M.,McHugh, N.A.,Favreau, L.,Strickland, C.,Voigt, J. Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor. Bioorg.Med.Chem.Lett., 18:418-422, 2008 Cited by PubMed: 17980584DOI: 10.1016/j.bmcl.2007.10.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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