2QHX

Structure of Pteridine Reductase from Leishmania major complexed with a ligand

2QHX の概要

• エントリーDOI: 10.2210/pdb2qhx/pdb
• 関連するPDBエントリー: 1E92 1W0C 2ATD 2BFA 2BFM 2BFP
• 分子名称: Pteridine reductase 1, IODIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, short-chain dehydrogenase/reductase, pteridine reductase, trypanosomatid, pterin salvage, drug resistance, methotrexate resistance, enzyme inhibitor, nadp/nadph
• 由来する生物種: Leishmania major
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 144162.51

構造登録者

Gibellini, F.,Mcluskey, K.,Tulloch, L.,Hunter, W.N. (登録日: 2007-07-03, 公開日: 2007-12-25, 最終更新日: 2024-02-21)

• 主引用文献: Cavazzuti, A.,Paglietti, G.,Hunter, W.N.,Gamarro, F.,Piras, S.,Loriga, M.,Allecca, S.,Corona, P.,McLuskey, K.,Tulloch, L.,Gibellini, F.,Ferrari, S.,Costi, M.P.; Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development.; Proc.Natl.Acad.Sci.USA, 105:1448-1453, 2008; PubMed: 18245389; DOI: 10.1073/pnas.0704384105

実験手法

X-RAY DIFFRACTION (2.61 Å)