2QHM

crystal structure of Chek1 in complex with inhibitor 2a

Summary for 2QHM

• Entry DOI: 10.2210/pdb2qhm/pdb
• Related: 2QHN
• Descriptor: Serine/threonine-protein kinase Chk1, (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE (3 entities in total)
• Functional Keywords: chek1, kinase, cell cycle checkpoint, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: O14757
• Total number of polymer chains: 1
• Total formula weight: 37207.49

Authors

Yan, Y.,Munshi, S. (deposition date: 2007-07-02, release date: 2008-03-18, Last modification date: 2023-08-30)

• Primary citation: Brnardic, E.J.,Garbaccio, R.M.,Fraley, M.E.,Tasber, E.S.,Steen, J.T.,Arrington, K.L.,Dudkin, V.Y.,Hartman, G.D.,Stirdivant, S.M.,Drakas, B.A.,Rickert, K.,Walsh, E.S.,Hamilton, K.,Buser, C.A.,Hardwick, J.,Tao, W.,Beck, S.C.,Mao, X.,Lobell, R.B.,Sepp-Lorenzino, L.,Yan, Y.,Ikuta, M.,Munshi, S.K.,Kuo, L.C.,Kreatsoulas, C.; Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors.; Bioorg.Med.Chem.Lett., 17:5989-5994, 2007; PubMed: 17804227; DOI: 10.1016/j.bmcl.2007.07.051

Experimental method

X-RAY DIFFRACTION (2 Å)