2QHM
crystal structure of Chek1 in complex with inhibitor 2a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase Chk1 | polymer | 323 | 36922.2 | 1 | UniProt (O14757) Pfam (PF00069) | Homo sapiens (human) | |
| 2 | B (A) | (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE | non-polymer | 285.3 | 1 | Chemie (7CS) | |||
| 3 | C (A) | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A: 1 - 307 (UniProt: O14757)
| PDB | External Database | Details |
|---|---|---|
| Arg 308 | - | expression tag |
| Thr 309 | - | expression tag |
| Pro 310 | - | expression tag |
| Gly 311 | - | expression tag |
| Ser 312 | - | expression tag |
| Gly 313 | - | expression tag |
| Trp 314 | - | expression tag |
| Ser 315 | - | expression tag |
| Lys 316 | - | expression tag |
| Glu 317 | - | expression tag |
| His 318 | - | expression tag |
| His 319 | - | expression tag |
| His 320 | - | expression tag |
| His 321 | - | expression tag |
| His 322 | - | expression tag |
| His 323 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36922.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 285.3 | |
| All* | Total formula weight | 37207.5 |
