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2Q70

Estrogen receptor alpha ligand-binding domain complxed to a benzopyran ligand

Summary for 2Q70
Entry DOI10.2210/pdb2q70/pdb
Related2I0J 2POG
DescriptorEstrogen receptor, (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (3 entities in total)
Functional Keywordstranscription factor, estrogen receptor, transcription
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Nucleus. Isoform 3: Nucleus: P03372
Total number of polymer chains2
Total formula weight57230.97
Authors
Wang, Y. (deposition date: 2007-06-05, release date: 2007-08-07, Last modification date: 2024-02-21)
Primary citationRichardson, T.I.,Dodge, J.A.,Durst, G.L.,Pfeifer, L.A.,Shah, J.,Wang, Y.,Durbin, J.D.,Krishnan, V.,Norman, B.H.
Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 3: synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification.
Bioorg.Med.Chem.Lett., 17:4824-4828, 2007
Cited by
PubMed: 17614275
DOI: 10.1016/j.bmcl.2007.06.052
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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