2Q61
Crystal Structure of PPARgamma ligand binding domain bound to partial agonist SR145
Summary for 2Q61
Entry DOI | 10.2210/pdb2q61/pdb |
Related | 2Q59 2Q5P 2Q5S 2Q6R 2Q6S |
Descriptor | Peroxisome Proliferator-Activated Receptor gamma, 1-BENZYL-5-CHLORO-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | protein-ligand complex, ligand binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 63378.40 |
Authors | Bruning, J.B.,Nettles, K.W. (deposition date: 2007-06-04, release date: 2007-10-23, Last modification date: 2023-08-30) |
Primary citation | Bruning, J.B.,Chalmers, M.J.,Prasad, S.,Busby, S.A.,Kamenecka, T.M.,He, Y.,Nettles, K.W.,Griffin, P.R. Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism Structure, 15:1258-1271, 2007 Cited by PubMed: 17937915DOI: 10.1016/j.str.2007.07.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.197 Å) |
Structure validation
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