2Q5P
Crystal Structure of PPARgamma bound to partial agonist MRL24
Summary for 2Q5P
Entry DOI | 10.2210/pdb2q5p/pdb |
Related | 2Q59 2Q5S 2Q61 2Q6R 2Q6S |
Descriptor | Peroxisome Proliferator-Activated Receptor gamma, (2S)-2-(3-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID (3 entities in total) |
Functional Keywords | protein-ligand complex, ligand binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 63645.60 |
Authors | Bruning, J.B.,Nettles, K.W. (deposition date: 2007-06-01, release date: 2007-10-23, Last modification date: 2023-08-30) |
Primary citation | Bruning, J.B.,Chalmers, M.J.,Prasad, S.,Busby, S.A.,Kamenecka, T.M.,He, Y.,Nettles, K.W.,Griffin, P.R. Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism Structure, 15:1258-1271, 2007 Cited by PubMed: 17937915DOI: 10.1016/j.str.2007.07.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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