2PXI

Ternary complex of DNA polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-monofluoromethylene triphosphate

Summary for 2PXI

• Entry DOI: 10.2210/pdb2pxi/pdb
• Related: 2ISO 2ISP
• Descriptor: 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... (9 entities in total)
• Functional Keywords: nucleotidyl transferase, dna polymerase, chiral interaction, stereoselectivity, lyase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 48445.58

Authors

McKenna, C.E.,Batra, V.K.,Beard, W.A.,Pedersen, L.C.,Wilson, S.H. (deposition date: 2007-05-14, release date: 2008-01-08, Last modification date: 2023-08-30)

• Primary citation: McKenna, C.E.,Kashemirov, B.A.,Upton, T.G.,Batra, V.K.,Goodman, M.F.,Pedersen, L.C.,Beard, W.A.,Wilson, S.H.; (R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta.; J.Am.Chem.Soc., 129:15412-15413, 2007; PubMed: 18031037; DOI: 10.1021/ja072127v

Experimental method

X-RAY DIFFRACTION (2.1 Å)