2ISP
Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-methylene triphosphate
Summary for 2ISP
Entry DOI | 10.2210/pdb2isp/pdb |
Related | 2ISO |
Descriptor | 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... (9 entities in total) |
Functional Keywords | nucleotidyl transferase, dna polymerase, leaving-group, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 48427.59 |
Authors | Sucato, C.A.,Upton, T.G.,Kashemirov, B.A.,Martinek, V.,Xiang, Y.,Beard, W.A. (deposition date: 2006-10-18, release date: 2007-01-30, Last modification date: 2023-08-30) |
Primary citation | Sucato, C.A.,Upton, T.G.,Kashemirov, B.A.,Batra, V.K.,Martinek, V.,Xiang, Y.,Beard, W.A.,Pedersen, L.C.,Wilson, S.H.,McKenna, C.E.,Florian, J.,Warshel, A.,Goodman, M.F. Modifying the beta,gamma Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase beta. Biochemistry, 46:461-471, 2007 Cited by PubMed: 17209556DOI: 10.1021/bi061517b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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