2PE0

CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 5-Hydroxy-3-[1-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-1,3-dihydro-indol-2-one COMPLEX

2PE0 の概要

• エントリーDOI: 10.2210/pdb2pe0/pdb
• 関連するPDBエントリー: 1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1Z5M 2PE1 2PE2
• 分子名称: 3-phosphoinositide-dependent protein kinase 1, SULFATE ION, 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE, ... (5 entities in total)
• 機能のキーワード: protein inhibitor complex, serine kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: O15530
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33838.78

構造登録者

Whitlow, M.,Adler, M. (登録日: 2007-04-01, 公開日: 2007-06-12, 最終更新日: 2011-07-13)

• 主引用文献: Islam, I.,Bryant, J.,Chou, Y.L.,Kochanny, M.J.,Lee, W.,Phillips, G.B.,Yu, H.,Adler, M.,Whitlow, M.,Ho, E.,Lentz, D.,Polokoff, M.A.,Subramanyam, B.,Wu, J.M.,Zhu, D.,Feldman, R.I.,Arnaiz, D.O.; Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity.; Bioorg.Med.Chem.Lett., 17:3814-3818, 2007; PubMed: 17531483; DOI: 10.1016/j.bmcl.2007.04.071

実験手法

X-RAY DIFFRACTION (2.35 Å)