2PDQ
Human aldose reductase mutant C303D complexed with uracil-type inhibitor.
Summary for 2PDQ
Entry DOI | 10.2210/pdb2pdq/pdb |
Related | 2PD5 2PD9 2PDB 2PDC 2PDF 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDL 2PDM 2PDN 2PDP 2PDU 2PDW 2PDX 2PDY |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID, ... (4 entities in total) |
Functional Keywords | tim barrel, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37005.46 |
Authors | Steuber, H.,Heine, A.,Klebe, G. (deposition date: 2007-04-01, release date: 2008-04-01, Last modification date: 2023-08-30) |
Primary citation | Steuber, H.,Heine, A.,Podjarny, A.,Klebe, G. Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. J.Mol.Biol., 379:991-1016, 2008 Cited by PubMed: 18495158DOI: 10.1016/j.jmb.2008.03.063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)