2PDQ
Human aldose reductase mutant C303D complexed with uracil-type inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aldose reductase | polymer | 316 | 35910.3 | 1 | UniProt (P15121) Pfam (PF00248) In PDB | Homo sapiens (human) | AR, Aldehyde reductase |
| 2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | A | {3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID | non-polymer | 351.8 | 1 | Chemie (47D) | |||
| 4 | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
A: 0 - 315 (UniProt: P15121)
| PDB | External Database | Details |
|---|---|---|
| Ile 4 | Leu 5 | conflict |
| Asp 303 | Cys 304 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35910.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1095.2 | |
| All* | Total formula weight | 37005.5 |
