2P4Y
Crystal structure of human PPAR-gamma-ligand binding domain complexed with an indole-based modulator
Summary for 2P4Y
Entry DOI | 10.2210/pdb2p4y/pdb |
Related | 1ZEO |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2R)-2-(4-CHLORO-3-{[3-(6-METHOXY-1,2-BENZISOXAZOL-3-YL)-2-METHYL-6-(TRIFLUOROMETHOXY)-1H-INDOL-1-YL]METHYL}PHENOXY)PROPANOIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total) |
Functional Keywords | nuclear receptor, ligand binding domain, lbd, alpha helix sandwich, ppar-homodimer, sppargm, partial agonist, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 64459.30 |
Authors | McKeever, B.M. (deposition date: 2007-03-13, release date: 2008-01-08, Last modification date: 2024-04-03) |
Primary citation | Einstein, M.,Akiyama, T.E.,Castriota, G.A.,Wang, C.F.,McKeever, B.,Mosley, R.T.,Becker, J.W.,Moller, D.E.,Meinke, P.T.,Wood, H.B.,Berger, J.P. The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities. Mol.Pharmacol., 73:62-74, 2008 Cited by PubMed: 17940191DOI: 10.1124/mol.107.041202 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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