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2P4Y

Crystal structure of human PPAR-gamma-ligand binding domain complexed with an indole-based modulator

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BPeroxisome proliferator-activated receptor gammapolymer27731593.62UniProt (P37231)
Pfam (PF00104)
In PDB
Homo sapiens (human)PPAR-gamma
2A, B(2R)-2-(4-CHLORO-3-{[3-(6-METHOXY-1,2-BENZISOXAZOL-3-YL)-2-METHYL-6-(TRIFLUOROMETHOXY)-1H-INDOL-1-YL]METHYL}PHENOXY)PROPANOIC ACIDnon-polymer574.92Chemie (C03)
3A2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOLnon-polymer122.11Chemie (TRS)
4waterwater18.093Chemie (HOH)
Sequence modifications
A, B: 203 - 477 (UniProt: P37231)
PDBExternal DatabaseDetails
Gly 201-expression tag
Ser 202-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight63187.3
Non-Polymers*Number of molecules3
Total formula weight1272.0
All*Total formula weight64459.3
*Water molecules are not included.

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PDB entries from 2024-03-27

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