2P4A

X-ray structure of a camelid affinity matured single-domain vhh antibody fragment in complex with RNASE A

Summary for 2P4A

Entry DOI	10.2210/pdb2p4a/pdb
Descriptor	Ribonuclease pancreatic, ANTIBODY CAB-RN05, SULFATE ION, ... (4 entities in total)
Functional Keywords	camelid single-domain antibody, vhh, cab-rn05, rnase a, paratope, yeast surface display, hydrolase-immune system complex, hydrolase/immune system
Biological source	Camelus dromedarius (Arabian camel) More
Cellular location	Secreted: P61823
Total number of polymer chains	4
Total formula weight	53269.33
Authors	Tereshko, V.,Koide, A.,Uysal, S.,Koide, S. (deposition date: 2007-03-11, release date: 2007-08-28, Last modification date: 2023-08-30)
Primary citation	Koide, A.,Tereshko, V.,Uysal, S.,Margalef, K.,Kossiakoff, A.A.,Koide, S. Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. J.Mol.Biol., 373:941-953, 2007 Cited by PubMed: 17888451 DOI: 10.1016/j.jmb.2007.08.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation