2P4A
X-ray structure of a camelid affinity matured single-domain vhh antibody fragment in complex with RNASE A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0004519 | molecular_function | endonuclease activity |
A | 0004522 | molecular_function | ribonuclease A activity |
A | 0004540 | molecular_function | RNA nuclease activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0016829 | molecular_function | lyase activity |
A | 0050830 | biological_process | defense response to Gram-positive bacterium |
B | 0002250 | biological_process | adaptive immune response |
B | 0003823 | molecular_function | antigen binding |
B | 0016064 | biological_process | immunoglobulin mediated immune response |
B | 0019814 | cellular_component | immunoglobulin complex |
B | 0072562 | cellular_component | blood microparticle |
C | 0003676 | molecular_function | nucleic acid binding |
C | 0004519 | molecular_function | endonuclease activity |
C | 0004522 | molecular_function | ribonuclease A activity |
C | 0004540 | molecular_function | RNA nuclease activity |
C | 0005515 | molecular_function | protein binding |
C | 0005576 | cellular_component | extracellular region |
C | 0016829 | molecular_function | lyase activity |
C | 0050830 | biological_process | defense response to Gram-positive bacterium |
D | 0002250 | biological_process | adaptive immune response |
D | 0003823 | molecular_function | antigen binding |
D | 0016064 | biological_process | immunoglobulin mediated immune response |
D | 0019814 | cellular_component | immunoglobulin complex |
D | 0072562 | cellular_component | blood microparticle |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 125 |
Chain | Residue |
A | GLN11 |
A | HIS12 |
A | LYS41 |
A | HIS119 |
A | HOH132 |
A | HOH204 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 C 125 |
Chain | Residue |
C | HOH135 |
C | HOH211 |
C | GLN11 |
C | LYS41 |
C | HIS119 |
Functional Information from PROSITE/UniProt
site_id | PS00127 |
Number of Residues | 7 |
Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF |
Chain | Residue | Details |
A | CYS40-PHE46 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | HIS12 | |
C | HIS12 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor |
Chain | Residue | Details |
A | HIS119 | |
C | HIS119 |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | BINDING: |
Chain | Residue | Details |
A | LYS7 | |
C | ARG85 | |
A | ARG10 | |
A | LYS41 | |
A | LYS66 | |
A | ARG85 | |
C | LYS7 | |
C | ARG10 | |
C | LYS41 | |
C | LYS66 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 |
Chain | Residue | Details |
A | LYS1 | |
A | LYS7 | |
A | LYS37 | |
A | LYS41 | |
C | LYS1 | |
C | LYS7 | |
C | LYS37 | |
C | LYS41 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:19358553 |
Chain | Residue | Details |
A | ASN34 | |
C | ASN34 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1rbn |
Chain | Residue | Details |
A | PHE120 | |
A | HIS119 | |
A | HIS12 | |
A | LYS41 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1rbn |
Chain | Residue | Details |
C | PHE120 | |
C | HIS119 | |
C | HIS12 | |
C | LYS41 |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1rbn |
Chain | Residue | Details |
A | HIS119 | |
A | HIS12 | |
A | LYS41 |
site_id | CSA4 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1rbn |
Chain | Residue | Details |
C | HIS119 | |
C | HIS12 | |
C | LYS41 |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 164 |
Chain | Residue | Details |
A | HIS12 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | LYS41 | electrostatic stabiliser, hydrogen bond donor |
A | HIS119 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | PHE120 | electrostatic stabiliser, hydrogen bond donor |
A | ASP121 | electrostatic stabiliser, hydrogen bond acceptor |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 164 |
Chain | Residue | Details |
C | HIS12 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
C | LYS41 | electrostatic stabiliser, hydrogen bond donor |
C | HIS119 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
C | PHE120 | electrostatic stabiliser, hydrogen bond donor |
C | ASP121 | electrostatic stabiliser, hydrogen bond acceptor |