2OZ5

Crystal structure of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB in complex with the specific inhibitor OMTS

Summary for 2OZ5

Entry DOI	10.2210/pdb2oz5/pdb
Descriptor	Phosphotyrosine protein phosphatase ptpb, {(3-CHLOROBENZYL)[(5-{[(3,3-DIPHENYLPROPYL)AMINO]SULFONYL}-2-THIENYL)METHYL]AMINO}(OXO)ACETIC ACID (3 entities in total)
Functional Keywords	protein tyrosine phosphatase in complex with small molecule inhibitor, structural genomics, tb structural genomics consortium, tbsgc, unknown function
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	67062.85
Authors	Grundner, C.,Gee, C.L.,Alber, T.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2007-02-23, release date: 2007-05-01, Last modification date: 2024-02-21)
Primary citation	Grundner, C.,Perrin, D.,Hooft van Huijsduijnen, R.,Swinnen, D.,Gonzalez, J.,Gee, C.L.,Wells, T.N.,Alber, T. Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB. Structure, 15:499-509, 2007 Cited by PubMed: 17437721 DOI: 10.1016/j.str.2007.03.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation