2OZ5
Crystal structure of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB in complex with the specific inhibitor OMTS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004438 | molecular_function | phosphatidylinositol-3-phosphate phosphatase activity |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0034594 | molecular_function | phosphatidylinositol trisphosphate phosphatase activity |
| A | 0051701 | biological_process | biological process involved in interaction with host |
| B | 0004438 | molecular_function | phosphatidylinositol-3-phosphate phosphatase activity |
| B | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| B | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
| B | 0016791 | molecular_function | phosphatase activity |
| B | 0034594 | molecular_function | phosphatidylinositol trisphosphate phosphatase activity |
| B | 0051701 | biological_process | biological process involved in interaction with host |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 7XY B 277 |
| Chain | Residue |
| B | SER57 |
| B | PHE133 |
| B | CYS160 |
| B | PHE161 |
| B | ALA162 |
| B | GLY163 |
| B | LYS164 |
| B | ASP165 |
| B | ARG166 |
| B | ILE203 |
| B | VAL231 |
| B | ARG59 |
| B | 7XY278 |
| B | HOH358 |
| B | HOH382 |
| B | GLU60 |
| B | PRO81 |
| B | HIS94 |
| B | PHE98 |
| B | LEU101 |
| B | TYR125 |
| B | GLU129 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 7XY B 278 |
| Chain | Residue |
| A | LEU215 |
| A | GLU218 |
| A | HOH281 |
| A | HOH381 |
| B | ARG59 |
| B | GLU60 |
| B | ARG63 |
| B | GLU95 |
| B | PHE161 |
| B | MET206 |
| B | ARG210 |
| B | PHE211 |
| B | 7XY277 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 7XY A 277 |
| Chain | Residue |
| A | SER57 |
| A | ARG59 |
| A | GLU60 |
| A | PRO81 |
| A | HIS94 |
| A | LEU101 |
| A | TYR125 |
| A | GLU129 |
| A | PHE133 |
| A | CYS160 |
| A | PHE161 |
| A | ALA162 |
| A | GLY163 |
| A | LYS164 |
| A | ASP165 |
| A | ARG166 |
| A | ILE203 |
| A | LEU227 |
| A | VAL231 |
| A | 7XY278 |
| A | HOH394 |
| A | HOH453 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 7XY A 278 |
| Chain | Residue |
| A | ARG59 |
| A | GLU60 |
| A | ARG63 |
| A | ARG64 |
| A | GLU95 |
| A | PHE98 |
| A | PHE161 |
| A | MET206 |
| A | ARG210 |
| A | PHE211 |
| A | LEU227 |
| A | 7XY277 |
| A | HOH294 |
| A | HOH298 |
| B | ALA216 |
| B | GLU218 |
| B | VAL219 |
