2OZ5

Crystal structure of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB in complex with the specific inhibitor OMTS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Phosphotyrosine protein phosphatase ptpb	polymer	296	32365.2	2	UniProt (A1QMT0) Pfam (PF13350) UniProt (by SIFTS) (P96830) In PDB	Mycobacterium tuberculosis
2	A, B	{(3-CHLOROBENZYL)[(5-{[(3,3-DIPHENYLPROPYL)AMINO]SULFONYL}-2-THIENYL)METHYL]AMINO}(OXO)ACETIC ACID	non-polymer		583.1	4	Chemie (7XY)
3		water	water		18.0	360	Chemie (HOH)

Sequence modifications

A, B: 1 - 276 (UniProt: A1QMT0)

PDB	External Database	Details
Met -19	-	cloning artifact
Gly -18	-	cloning artifact
Ser -17	-	cloning artifact
Ser -16	-	cloning artifact
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	cloning artifact
Ser -8	-	cloning artifact
Gly -7	-	cloning artifact
Leu -6	-	cloning artifact
Val -5	-	cloning artifact
Pro -4	-	cloning artifact
Arg -3	-	cloning artifact
Gly -2	-	cloning artifact
Ser -1	-	cloning artifact
His 0	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	64730.4
Non-Polymers*	Number of molecules	4
	Total formula weight	2332.5
All*	Total formula weight	67062.9

*Water molecules are not included.