2OAX
Crystal structure of the S810L mutant mineralocorticoid receptor associated with SC9420
Summary for 2OAX
Entry DOI | 10.2210/pdb2oax/pdb |
Descriptor | Mineralocorticoid receptor, SPIRONOLACTONE (3 entities in total) |
Functional Keywords | aldosterone; steroid receptor; nuclear receptor; transcription factor; activating mutation, hypertension; antagonist; spironolactone, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P08235 |
Total number of polymer chains | 6 |
Total formula weight | 180707.90 |
Authors | Huyet, J.,Pinon, G.M.,Fay, M.R.,Rafestin-Oblin, M.E.,Fagart, J. (deposition date: 2006-12-18, release date: 2007-08-14, Last modification date: 2023-08-30) |
Primary citation | Huyet, J.,Pinon, G.M.,Fay, M.R.,Fagart, J.,Rafestin-Oblin, M.E. Structural basis of spirolactone recognition by the mineralocorticoid receptor Mol.Pharmacol., 72:563-571, 2007 Cited by PubMed: 17569793DOI: 10.1124/mol.107.036459 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
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