2OAX
Crystal structure of the S810L mutant mineralocorticoid receptor associated with SC9420
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SNL A 1001 |
| Chain | Residue |
| A | LEU766 |
| A | MET845 |
| A | LEU848 |
| A | CYS849 |
| A | LEU938 |
| A | PHE941 |
| A | CYS942 |
| A | THR945 |
| A | PHE956 |
| A | LEU769 |
| A | ASN770 |
| A | GLN776 |
| A | MET807 |
| A | LEU810 |
| A | LEU814 |
| A | ARG817 |
| A | PHE829 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SNL B 2001 |
| Chain | Residue |
| B | LEU766 |
| B | LEU769 |
| B | ASN770 |
| B | GLN776 |
| B | MET807 |
| B | LEU810 |
| B | LEU814 |
| B | ARG817 |
| B | PHE829 |
| B | MET852 |
| B | LEU938 |
| B | PHE941 |
| B | CYS942 |
| B | THR945 |
| B | PHE956 |
| B | HOH7301 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SNL C 3001 |
| Chain | Residue |
| C | LEU769 |
| C | ASN770 |
| C | ALA773 |
| C | GLN776 |
| C | MET807 |
| C | LEU810 |
| C | ARG817 |
| C | PHE829 |
| C | MET845 |
| C | LEU848 |
| C | CYS849 |
| C | MET852 |
| C | LEU938 |
| C | PHE941 |
| C | CYS942 |
| C | PHE956 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SNL D 4001 |
| Chain | Residue |
| D | LEU766 |
| D | LEU769 |
| D | ASN770 |
| D | LEU772 |
| D | GLN776 |
| D | TRP806 |
| D | MET807 |
| D | LEU810 |
| D | LEU814 |
| D | ARG817 |
| D | PHE829 |
| D | MET852 |
| D | LEU938 |
| D | PHE941 |
| D | CYS942 |
| D | PHE956 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SNL E 5001 |
| Chain | Residue |
| E | LEU766 |
| E | LEU769 |
| E | ASN770 |
| E | LEU772 |
| E | GLN776 |
| E | MET807 |
| E | LEU810 |
| E | LEU814 |
| E | ARG817 |
| E | PHE829 |
| E | MET845 |
| E | MET852 |
| E | LEU938 |
| E | PHE941 |
| E | CYS942 |
| E | PHE956 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SNL F 6001 |
| Chain | Residue |
| F | LEU766 |
| F | LEU769 |
| F | ASN770 |
| F | LEU772 |
| F | ALA773 |
| F | GLN776 |
| F | MET807 |
| F | LEU810 |
| F | ARG817 |
| F | PHE829 |
| F | MET845 |
| F | LEU848 |
| F | CYS849 |
| F | LEU938 |
| F | PHE941 |
| F | CYS942 |
| F | PHE956 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Region: {"description":"Important for coactivator binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15908963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15967794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15967794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
