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2NVD

Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (2)

Summary for 2NVD
Entry DOI10.2210/pdb2nvd/pdb
Related2FZD 2NVC
DescriptorAldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE, ... (4 entities in total)
Functional Keywordsaldose reductase, tim-barrel, protein-ligand complex, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P15121
Total number of polymer chains1
Total formula weight37647.61
Authors
Steuber, H.,Heine, A.,Klebe, G. (deposition date: 2006-11-12, release date: 2007-04-24, Last modification date: 2023-10-25)
Primary citationSteuber, H.,Zentgraf, M.,La Motta, C.,Sartini, S.,Heine, A.,Klebe, G.
Evidence for a novel binding site conformer of aldose reductase in ligand-bound state
J.Mol.Biol., 369:186-197, 2007
Cited by
PubMed: 17418233
DOI: 10.1016/j.jmb.2007.03.021
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

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