2NVC
Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (3)
Summary for 2NVC
Entry DOI | 10.2210/pdb2nvc/pdb |
Related | 2FZD 2NVD |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID, ... (4 entities in total) |
Functional Keywords | tim barrel, protein-ligand complex, aldose reductase, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37035.07 |
Authors | Steuber, H.,Heine, A.,Klebe, G. (deposition date: 2006-11-12, release date: 2007-04-24, Last modification date: 2023-10-25) |
Primary citation | Steuber, H.,Zentgraf, M.,La Motta, C.,Sartini, S.,Heine, A.,Klebe, G. Evidence for a novel binding site conformer of aldose reductase in ligand-bound state J.Mol.Biol., 369:186-197, 2007 Cited by PubMed: 17418233DOI: 10.1016/j.jmb.2007.03.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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