2NVC
Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (3)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Aldose reductase | polymer | 316 | 35898.3 | 1 | UniProt (P15121) Pfam (PF00248) In PDB | Homo sapiens (human) | AR, Aldehyde reductase |
2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
3 | A | {4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID | non-polymer | 393.3 | 1 | Chemie (ITA) | |||
4 | water | water | 18.0 | 247 | Chemie (HOH) |
Sequence modifications
A: 0 - 315 (UniProt: P15121)
PDB | External Database | Details |
---|---|---|
Ile 4 | Leu 4 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35898.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1136.7 | |
All* | Total formula weight | 37035.1 |