2NVC

Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (3)

Summary for 2NVC

Entry DOI	10.2210/pdb2nvc/pdb
Related	2FZD 2NVD
Descriptor	Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID, ... (4 entities in total)
Functional Keywords	tim barrel, protein-ligand complex, aldose reductase, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37035.07
Authors	Steuber, H.,Heine, A.,Klebe, G. (deposition date: 2006-11-12, release date: 2007-04-24, Last modification date: 2023-10-25)
Primary citation	Steuber, H.,Zentgraf, M.,La Motta, C.,Sartini, S.,Heine, A.,Klebe, G. Evidence for a novel binding site conformer of aldose reductase in ligand-bound state J.Mol.Biol., 369:186-197, 2007 Cited by PubMed: 17418233 DOI: 10.1016/j.jmb.2007.03.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation