2NPA
the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid
Summary for 2NPA
Entry DOI | 10.2210/pdb2npa/pdb |
Descriptor | Peroxisome proliferator-activated receptor alpha, SRC- peptide from Nuclear receptor coactivator 1, (2R,3E)-2-{4-[(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)METHOXY]BENZYL}-3-(PROPOXYIMINO)BUTANOIC ACID, ... (4 entities in total) |
Functional Keywords | protein-agonist complex, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q07869 |
Total number of polymer chains | 4 |
Total formula weight | 65596.55 |
Authors | |
Primary citation | Han, H.O.,Kim, S.H.,Kim, K.H.,Hur, G.C.,Yim, H.J.,Chung, H.K.,Woo, S.H.,Koo, K.D.,Lee, C.S.,Koh, J.S.,Kim, G.T. Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists Bioorg.Med.Chem.Lett., 17:937-941, 2007 Cited by PubMed: 17157019DOI: 10.1016/j.bmcl.2006.11.050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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